A new European study has found a link between long-term use of antidepressants and a significantly increased risk of sudden cardiac death (SCD). The study reported that individuals who used antidepressants for one to five years faced a 56 percent higher risk of sudden cardiac death compared to those who did not.

“These medications can have potential adverse effects such as QT prolongation — when the heart muscle takes longer to contract and relax — which may increase the risk for arrhythmic events, and in rare cases, SCD,” said Jasmin Mujkanovic, MD, one of the study’s lead researchers. “It is important to recognize that having depression is itself an independent risk factor for cardiovascular disease.”

Antidepressants have previously been associated with a range of side effects, including suicide. The study adds sudden cardiac death to the list of potential risks tied to long-term use.

Usage of antidepressants in the United States has steadily increased. According to the American Psychological Association, use rose 64 percent from 1999 to 2014. Current estimates suggest 12.7 percent of U.S. adults take antidepressants, with rates among seniors reaching 19.1 percent.

The rise in usage may be partially influenced by direct-to-consumer advertising. The United States is one of only three countries globally that allow pharmaceutical companies to market prescription drugs directly to the public.

Meanwhile, many Americans may remain unaware that holistic alternatives are actually viable options despite numerous studies confirming non drug approaches such as getting a good night’s sleep, exercising, and eating healthy are effective strategies for overcoming depression.

However, with sudden cardiac deaths remaining in the headlines, perhaps this new study will serve as the wake up call America needs to begin a conversation about whether our drug-based approach to mental health is working for us or whether it’s time to look more seriously at alternatives.